Ever since I've discovered what that program can do, I always run it on every brand new drive I get (after it's formatted) and I think it goes a long way to eliminate a lot of fuck-ups that can happen in the long term although, I don't really have any proof of that.
The only annoying thing is the time it needs to complete everything, but with multiple rigs, drives, Laptop, etc. Nowadays it's really a non issue.