The version 0.100.1 of Negatron, a MAME front-end, has just been released with new features.
Besides MAME internal UI, this is the only front-end that can manage all the configuration options of the emulated machines in MAME. In practice, it's often useless for arcade games but it's quite important for emulated consoles and computers.
To completely achieve this, Negatron needs to be coupled with NegaMAME, a fork that distinguishes itself from regular MAME only by adding the command line option -listmediaxml, which enables Negatron to access some information unavailable to third-party front-ends since MAME v0.186. In practice, you can simply copy negamame64.exe into your MAME install folder, everything else in the NegaMAME archive file is exactly the same as regular MAME.
Negatron's available at the Negatron webpage and NegaMAME at the NegaMAME webpage.